Ambak Kumar Rai

Associate Professor
Department of Biotechnology
Motilal Nehru National Institute of Technology Allahabad, Prayagraj, India-211004
E-mail: ambakrai[at]mnnit[dot]ac[dot]in
Telephone: +91-532-2271241(O) +91-8765787601(M)

Research Publications

Patents:

Title: A multipurpose low cost portable UV-C sanitization cabinet for home and office use, Authors: Sameer Srivastava, Ambak Kumar Rai , Ashutosh Mani, Nand Kumar Singh, Shivesh Sharma and Rajeev Tripathi, Field: Engineering and Technology; Filed on 2020-05-03, Status: Technology transferred

Title: Hand gloves removing device. Authors: Ambak Kumar Rai, Prof. Shivesh Sharma, Sameer Srivastava, Ashutosh Mani, Nand Kumar Singh, Prof. Rajeev Tripathi. Filed on 2020-05-05, Status: Technology transferred

Title: An improved anthropometrically designed face shield and a process thereof. Authors: Ambak Kumar Rai, Ashutosh Mani, Sameer Srivastava, Shivesh Sharma, Nand Kumar Singh, Rajeev Tripathi, Filed on 2020-05-08

Copyright title: AMRIT (Assessment, Monitoring, Reporting and Intelligent Tracking), Authors: Dr. Ashutosh Mani, Dr. Ambak Kumar Rai, Dr. Sameer Srivastava, Dr. Nand Kumar Singh, Prof. Shivesh Sharma, Prof. Geetika, Prof. Rajeev Tripathi; Filed 2020-05-26;

Book Chapter:

Immunology of Tuberculosis. In: Tuberculosis (2010) Mitra DK, Rai AK (S.K. Sharma Eds) JayPee Publication 2nd Edition 108-123 ISBN 978-81-8448-514-1

Factors Associated with Neuropsychological Impairment in HIV Infection. In: HIV infection/Book 4, Rai Y, Dutta T, Rai A K, Intech open access publishers, ISBN 979-953-307-190-8.

Failure of Optimum Activation in Aged T Cells Compromises Their Response to Antigens. In Current Challenges and Management of Diseases in the Elderly Population [Geriatric, Gerontology and Elderly Issue] Amit Kumar Kureel, Bharat Singh and Ambak Kumar Rai [Eds: Abhai Kumar], 2019 Nova Science Publishers

Intertwining of Retinoic Acid and Cholesterol Pathway and its Consequences in Leishmania donovani-Infected Macrophages. In Book titled Pathobiology of Parasitic Protozoa: Dynamics and Dimensions, Satya Prakash and Ambak Kumar Rai [Eds: Budhaditya Mukherjee, Arijit Bhattacharya, Rupkatha Mukhopadhyay and Bruno Guedes Alcoforado Aguiar], 2023 Springer Publishers

Regulation of T Cell Response in Inflammation from Killing to Healing [Chapter 4]. In Book titled ‘Inflammation Resolution and Chronic Diseases’, Smita Kumari and Ambak Kumar Rai [Eds:Tripathi, A., Dwivedi, A., Gupta, S., Poojan, S.], 2024, Springer Nature, ISBN: 978-981-97-0156-8 [Print], 978-981-97-0157-5 [Online]

Players of Inflammation in the Containment of Intracellular Infections [Chapter 3]. In Book titled ‘Inflammation Resolution and Chronic Diseases’, Sheetal Saini and Ambak Kumar Rai [Eds: Tripathi, A., Dwivedi, A., Gupta, S., Poojan, S.], 2024, Springer Nature, ISBN: 978-981-97-0156-8 [Print], 978-981-97-0157-5 [Online]

Journals:

M. Singh, A. K. Rai, S. M. Singh. Gender dimorphism in the progressive in vivo growth of a T cell lymphoma: involvement of cytokines and gonadal hormones. Journal of Reproductive Immunology, 2005, 65(1) ,17-32, Impact factor: 3.933

A.Panigrahi, J. A. Siddiqui, A. Rai, A. Margoob, Khaira A, D. Bhowmik, S.C. Tiwari, S. Guleria and N.K. Mehra. Allosensitization to HLA and MICA is an important measure of renal graft outcome. Clinical Transplants, 2007, 49-55, Impact factor: 2.863

Manju Sengar*, Ambak K. Rai*, Ankit Saxena, Amar Singh, Vinod Raina, Tulika Seth, Atul Sharma, Sameer Bakhsi, Rajive Kumar, Dipendra K. Mitra Acute leukemia: Diagnosis improved by flow cytometry in addition to morphology. Asia Pacific Journal of clinical Oncology, 2009; 5: 55–65, Impact factor: 2.601. * shared first author

Ankit Saxena, Ambak Rai, Vinod Raina, Tulika Seth and Dipendra Kumar Mitra Expression of CD13/Aminopeptidase N in precursor B cell leukemia: Role in growth regulation of B cells. Cancer Immunology and Immunotherapy, 2009, 59(1), 125-135, Impact factor: 6.968

Dipendra K Mitra, Beenu Joshi, Amit K Dinda, Ambak K. Rai, B K Girdhar, Kiran Katoch, Maninder S Bindra and Utpal Sengupta. Induction of lepromin reactivity in cured lepromatous leprosy patients: Impaired chemokine response dissociates protective immunity from delayed-type hypersensitivity. Microbes and Infection, 2009, 11(14-15), 1122-30, Impact factor: 9.570

C.P.Thakur, Amit Kumar, D.K. Mitra, Ambak K Rai, Arun K. Sinha and Alok Ranjan. Improving Outcome of Treatment of Kala-Azar by Supplementation of Amphotericin B with Physiologic Saline and Potassium Chloride. American Journal of Tropical Medicine and Hygiene, 2010, 83(5), 1040–1043, Impact factor: 2.345

A. K. Rai, C. P. Thakur, T. Seth, D. K. Mitra. Early activated Th-1 type and dominantly non-invariant natural killer T (CD3+CD161+Vα24-) cells in bone marrow among visceral leishmaniasis patients. International Journal of Parasitology, 2011, 41, 1069–1077, Impact factor: 4.33

Ambak K. Rai, Chandreshwar P. Thakur, T. Velpandian, Surendra K. Sharma, Balram Ghosh, Dipendra K. Mitra. High Concentration of Adenosine in Human Visceral Leishmaniasis: Despite Increased ADA and Decreased CD73. Parasite Immunology, 2011, 33 (11), 632-636, Impact factor: 2.280

Ambak Kumar Rai, Chandreshwar Prasad Thakur, Tulika Seth and Dipendra Kumar Mitra. Enrichment of Invariant NKT Cells in the Bone Marrow of Visceral Leishmaniasis Patients. Parasite Immunology, 2011, 33(12), 688-691, Impact factor: 2.280

Ambak K. Rai, Chandreshwar P. Thakur, Amar Singh, Tulika Seth, Sandeep K. Srivastava, Pushpendra Singh and Dipendra K. Mitra. Regulatory T Cells Suppress T Cell Activation at the Pathologic Site of Human Visceral Leishmaniasis. PloS ONE, 2010, 7(2), e31551. Impact factor: 3.752

Ambak K. Rai, Chandreshwar P. Thakur and Dipendra K. Mitra. Impaired Expression of CD26 Compromises T Cell Recruitment in Human Visceral Leishmaniasis. European Journal of Immunology, 2010, DOI: 10.1002/eji.201141912, Impact factor: 6.668

Ambak K. Rai, Shivesh Sharma and Vasu Punj. Orchestration of Host-Pathogen Interaction: Relevance of Iron in Generation of Potent Anti-M. tuberculosis Immunity. Current Pharmaceutical Biotechnology, 2014, 15(12), 1095-1104, Impact factor: 2.837

Praachi Tiwari, Pankaj Verma, Amit Kumar Kureel, Sheetal Saini, Ambak Kumar Rai. Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L. donovani. Molecular and Biochemical Parasitology, 2016, 207(2), 89–95, Impact factor: 1.759

Ambak K. Rai, Prabin Kumar, Sheetal Saini, Chandreshwar P. Thakur, Tulika Seth and Dipendra K. Mitra Increased level of soluble adenosine deaminase in bone marrow of visceral leishmaniasis patients: an inverse relation with parasite load. Acta Parasitologica, 2016, 61(3), 645–649, Impact factor: 1.440

Anil Kumar Jaiswal, K. Bhaskara Rao, Pragati Kushwaha, Keerti Rawat, Ram K. Modukuri, Prashant Khare, Sumit Joshi, Shikha Mishra, Ambak K. Rai, Koneni V. Sashidhara, Anuradha Dube. Development of Leishmania donovani stably expressing DsRed for flow cytometry-based drug screening using chalcone thiazolyl-hydrazone as a new antileishmanial target. International Journal of Antimicrobial Agents, 2016, 48, 695–702, Impact factor: 5.283

Ambak Kumar Rai, Dipendra Kumar Mitra. HIV induced suppression of host immunity: relevance to Mycobacterium tuberculosis infections. HIV & AIDS Review, 2017, 16(1), 1-15. Impact Factor: 0.32

Ambak Kumar Rai, Amar Singh, Ankit Saxena, Tulika Seth, Vinod Raina and Dipendra Kumar Mitra. Exonal switch down-regulates the expression of CD5 on blasts of acute T cell leukaemia. Clinical and Experimental Immunology, 2017,190 (3), 340-350. Impact factor: 5.732

Ambak Kumar Rai, Chandreshwar Prasad Thakur, Prabin Kumar, Sheetal Saini, Amit Kumar Kureel, Smita Kumari, Tulika Seth & Dipendra Kumar Mitra. Decrease in the Frequency of Circulating CD56+CD161+ NK Cells in Human Visceral Leishmaniasis. Immunological Investigations, 2017, 47 (2), 125-134. Impact factor: 3.657

Anu Singha, Lavkusha, Amit Kumar Kureel, P.K. Dutta, Sushil Kumar, Ambak Kumar Rai. Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anti-cancer activity. International Journal of Biological Macromolecules, 2018, 110, 234-244. Impact Factor: 6.953

K.J. Sindhu, Amit Kumar Kureel, Sheetal Saini, Smita Kumari, Pankaj Verma and Ambak Kumar Rai. Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite, Acta Parasitologica, 2018, 63(1), 75–88, Impact factor: 1.534

Anu Singh, P.K. Dutta, Hridyesh Kumar, Amit Kumar Kureel, Ambak Kumar Rai. Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. Carbohydrate Polymers, 2018, 193, 99–107. Impact factor : 10.732

Pankaj Verma, Amit Kumar Kureel, Sheetal Saini, Satya Prakash, Smita Kumari, Sarath Kumar Kottarath, Sandeep Kumar Srivastava, Madhusudan Bhat, Amit Kumar Dinda, Chandreshwar Prasad Thakur. Ambak K. Rai. Leishmania donovani reduces the level of Retinoic acid-synthesizing enzymes in infected macrophages and favoring its own survival. Parasitology Research 2019, 118(1), 63-71. Impact factor: 2.289

Kashika Arora, Ambak Kumar Rai. Dependence of Leishmania parasite on host derive ATP: An overview of extracellular nucleotide metabolism in parasite. Journal of Parasitic Diseases 2019, 43(1), 1-13

Amit Kumar Kureel, Smita Kumari, Sheetal Saini, Satyaprakash, Bharat Singh, Ambak Kumar Rai. Identification of a novel transcript variant of the human CD6 gene that lacks exon 9. Immunobiology. 2019 224 (5), 666-671. Impact factor: 3.144

Anu Singh, Pradip K Dutta, Hridyesh Kumar, Amit Kumar Kureel, Ambak Kumar Rai. Improved antibacterial and antioxidant activities of Gallic acid grafted chitin-glucan complex. Journal of Polymer Research 2019, 26(9), 234. Impact factor: 3.097

Sheetal Saini, Anuradha Dube, Amogh Anant Sahastrabuddhe, Chandreshwar Prasad Thakur, Sumit Joshi, Keerti Rawat, Ambak Kumar Rai. Comparison between immuno-clinicopethological features of experimental and human visceral leishmaniasis by Leishmania donovani. Acta Parasitologica 2019, 65 (1), 57-67. Impact factor: 1.534

Sheetal Saini, Sarath Kumar Kottarath, Amit Kumar Dinda, Anuradha Dube, Amogh Anant Sahastrabuddhe, Chandreshwar Prasad Thakur, Madhusudan Bhat, Ambak Kumar Rai, Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection, Biochimie, 2020, 175: 13-22. Impact factor: 4.372

Sheetal Saini, Ambak K Rai, Hamster, a close model for visceral leishmaniasis: Opportunities and Challenges, Parasite Immunology, 2020, 42 (10), e12768. Impact factor: 2.280

Sheetal Saini, Bharat Singh, Satya Prakash, Smita Kumari, Amit Kumar Kureel, Anuradha Dube, Amogh Anant Sahasrabuddhe, Ambak Kumar Rai. Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis. Prostaglandins Other Lipid Mediat. 2020 147, 106390. Impact factor: 3.072

Sheetal Saini, Sheetal Saini and Ambak Kumar Rai. Linoleic acid inhibits the release of Leishmania donovani derived micro vesicles and decreases its survival in macrophages. Frontiers in Cellular and Infection Microbiology 2020, 10: 406. Impact factor: 6.073

Abhishek Nigam, Sheetal Saini, Ambak Kumar Rai, S. J. Pawar. Structural, optical, cytotoxicity, and antimicrobial properties of MgO, ZnO and MgO/ZnO nanocomposite for biomedical applications. Ceramics International. 2021, 47 (14), 19515-19525. Impact factor: 5.532

Amit Kumar Kureel, Sheetal Saini, Bharat Singh, Kulwant Singh & Ambak Kumar Rai. Compromised levels of CD6 and reduced T cell activation in the aged immune system. Biomarkers, 26(5), 483-490. Impact factor: 2.658

Sheetal Saini and Ambak Kumar Rai. Linoleic Acid—A Feasible Preventive Approach for Visceral Leishmaniasis. Front. Nutr. 2021. Impact factor: 6.576

Abhishek Nigam, Sheetal Saini, Ambak Kumar Rai, S.J. Pawar, Structural, morphological, antimicrobial, and cytotoxicity study of spindle-shaped ZnO submicron particles for potential biomedical applications. Materials Today Communications, 2021, 28, 102683, Impact factor: 3.383

Satya Prakash, Sheetal Saini, Smita Kumari, Bharat Singh, Amit Kumar Kureel, Ambak Kumar Rai, Retinoic acid restores the levels of cellular cholesterol in Leishmania donovani infected macrophages by increasing npc1 and npc2 expressions, Biochimie, 2022, 198, 23-32. Impact factor: 4.372

Abhishek Nigam, Sheetal Saini, Ambak Kumar Rai, S.J. Pawar, Zinc doped magnesium ferrite nanoparticles for evaluation of biological properties viz antimicrobial, biocompatibility, and in vitro cytotoxicity. Materials Today Communications, 2022, 31, 103632, https://doi.org/10.1016/j.mtcomm.2022.103632. Impact factor: 3.383

Satya Prakash, Ambak Kumar Rai, Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner. Immunol Res, 2022. https://doi.org/10.1007/s12026-022-09292-x, Impact factor: 4.505

Kulwant Singh, Smita Kumari, Bharat Singh, Ranjeet Bahadur Choubey, Dipendra Kumar Mitra, Ambak Kumar Rai, Jurkat T cells are immunophenotypically distinct from T-cell acute lymphoblastic leukemia cells due to high-level surface expression of CD5. Cancer Investigation, 2022, 40(8):675-679. Impact factor: 2.368

Srishti Sahu, Bharat Singh, Ambak Kumar Rai, Human endogenous retrovirus, a tenant in our genome, regulates initiation and progression of cancers. Molecular and clinical Oncology, 2022, 17, 143. Impact factor: 1.629

Satya Prakash, Ambak Kumar Rai, Retinoic acid increases the cellular cholesterol in Leishmania donovani infected macrophages in mTOR independent manner. Microbiology Spectrum, 2022,10(6):e0269922. Impact Factor: 9.043,

Bharat Singh, Ambak Kumar Rai, Loss of immune regulation in aged T-cells: A metabolic review to show lack of ability to control responses within the self. Human Immunology, 2022, 83, 808–817. Impact factor 2.211

Sheetal Saini, Bharat Singh, Anuradha Dube, Amogh Anant Sahasrabuddhe, Ambak Kumar Rai, Organ-specific immune profiling of Leishmania donovani-infected hamsters. Parasite Immunol. 2023; e12964. Impact Factor 2.28

Sarita Singh, Ambak K. Rai and Ravi Prakash Tewari, Recent advancement in hyaluronic acid-based hydrogel for biomedical engineering application: A mini-review, Materials Today: Proceedings, 2023, https://doi.org/10.1016/j.matpr.2022.12.208

Satya Prakash and Ambak Kumar Rai, Retinoic acid shows direct parasiticidal activity by targeting ergosterol pathway in Leishmania donovani: A potential therapeutic advancement. Journal of Biomolecular Structure & Dynamics, 2023 [Accepted], Impact factor: 5.235

Bharat Singh & Ambak Kumar Rai, Physiological Consequences of Immune Aging at Organs Level: A Mini-review. Indian Journal of Experimental Biology, 2023 Vol. 61, 667-672, DOI: 10.56042/ijeb.v61i09.3638, Impact factor: 0.944

Smita Kumari, Srishti Sahu, Bharat Singh, Swarnima Gupta, Amit Kumar Kureel, Ankit Srivastava, Deeksha Rikhari, Sameer Srivastava, Ambak Kumar Rai. HIF-1α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: a potential mechanism for CD5neg/low phenotype of infiltrating cells in solid tumors. Cellular Immunology, 2023, 391–392, 104755, Impact factor: 4.30

Shekhar A, Singh S, Gupta K, et al. Comprehensive Review of Available Nanotechnological Techniques for Treating Nonsolid Tumors. Nano Biomedicine and Engineering, 2023, 15(2): 191-198. https://doi.org/10.26599/NBE.2023.9290023

Sarita, D., P. M., Singh, B., Rai, A. K., Tewari, R. P., & Dutta, P. K. (2024). An injectable blend hydrogel for bone tissue engineering application: synthesis and characterization. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 2023, 61(1), 2–10. https://doi.org/10.1080/10601325.2023.2277211

Sarita, Ambak K. Rai, and Ravi Prakash Tewari, Different approaches in bone tissue engineering: advantages and disadvantages. Biomedical Engineering: Applications, Basis and Communications, 2024, 36 (02), 2430001 https://doi.org/10.1080/10601325.2023.2277211

Smita Kumari, Bharat Singh, Amit Kumar Kureel, Sheetal Saini, Satya Prakash, Aditi Chauhan, Prabin Kumar, Kulwant Singh, Ambak Kumar Rai, Benzo[a]pyrene exposure causes exonal switch resulting in reduced surface CD5 expression in an AHR-dependent manner. Immunology letters, 2024, 267, 106858, 10.1016/j.imlet.2024.106858

Conference Proceedings:

F. 107. Impairment of Stimulation Dependent Induction of CD26 Compromises T Cell Recruitment in Human Visceral Leishmaniasis. AK Rai, S Srivastva, A Singh, C Thakur, D Mitra. Clinical Immunology, S78. Impact factor: 3.969

Humoral Immune Response Mediated by Antidonor, Anti HLA and MICA Antibody Repertoire is Associated with Renal Allograft Rejection. A Panigrahi, J Shidhiki, A Rai, A Margoob, D Bhowmik, SC Dash, S Guleria, SN Mehta, NK Mehra. Indian Journal of Transplantation, 2008, 30.

Ambak Kumar Rai, K J Sindhu, A K Kureel, S Saini, S Kumari and P Verma, Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite, Journal of Infectious Diseases & Therapy, 2017, 5:2